Publications

2024

Charlton-Sevcik AK, Collom C, Liu JY, Hsieh YL, Stark N, Ede JD, Shatkin JA, Sayes CM. The impact of surface functionalization of cellulose following simulated digestion and gastrointestinal cell-based model exposure. International Journal of Biological Macromolecules. 2024 Jun 1;271:132603.

Liu JY, Pradhan SH, Zechmann B, Hussain S, Sayes CM. Lung surfactant inhibition and cytotoxicity at the air-liquid interface of dry particle aerosols. Journal of Aerosol Science. 2024 Jun 10:106419.

Liu JY, Sayes CM. Modeling mixtures interactions in environmental toxicology. Environmental Toxicology and Pharmacology. 2024 Feb 2:104380.

Zhang Y, Fox DM, Ong KJ, Ede J, Sayes C, Kangas H, Ilona L, Goergen M, Moon R, Shatkin JA. Limitations of recent cellulose studies: how overzealous dispersion technique, fluorescence labeling and interpretation limit the findings of recent safety assessments for cellulose materials. Trends in Food Science & Technology. 2024 Jul 9:104620.

Gibb M, Liu JY, Sayes CM. The transcriptomic signature of respiratory sensitizers using an alveolar model. Cell Biology and Toxicology. 2024 Apr 8;40(1):21.

Stevens D, Kramer AT, Coogan MA, Sayes CM. Developmental effects of zebrafish (Danio rerio) embryos after exposure to glyphosate and lead mixtures. Ecotoxicology and Environmental Safety. 2024 Feb 1;271:115886.

Lyons-Darden T, Heim KE, Han L, Haines L, Sayes CM, Oller AR. Bioaccessibility of Metallic Nickel and Nickel Oxide Nanoparticles in Four Simulated Biological Fluids. Nanomaterials. 2024 May 17;14(10):877.

Collom C, Fox D, Ong K, Shatkin JA, Sayes C. A comparative analysis of microfibrillated versus conventional cellulose after enzymatic digestions. Cellulose. 2024 May 28:1-5.

Beard JM, Collom C, Liu JY, Obiako P, Strongin RM, Zavala J, Sayes CM. In vitro toxicity and chemical analysis of e-cigarette aerosol produced amid dry hitting. Toxicology. 2024 Jun 13:153865.

Pingrey B, Ede JD, Sayes CM, Shatkin JA, Stark N, Hsieh YL. Aqueous exfoliation and dispersion of monolayer and bilayer graphene from graphite using sulfated cellulose nanofibrils. RSC advances. 2024;14(14):9860-8.

Liu JY, George IC, Hussain S, Sayes CM. High-throughput screening of respiratory hazards: Exploring lung surfactant inhibition with 20 benchmark chemicals. Toxicology. 2024 May 1;504:153785.

Guo M, Ede JD, Sayes CM, Shatkin JA, Stark N, Hsieh YL. Regioselectively Carboxylated Cellulose Nanofibril Models from Dissolving Pulp: C6 via TEMPO Oxidation and C2, C3 via Periodate–Chlorite Oxidation. Nanomaterials. 2024 Mar 6;14(5):479.

Baldovinos Y, Obiako P, Collom C, Sayes CM. A vape condensate collection method for degradant identification and toxicity screening. Journal of Hazardous Materials Letters. 2024 Nov 1;5:100099.

Liu J, Beard J, Hussain S, Sayes CM. Advancing Analytical and Graphical Methods for Binary and Ternary Mixtures: The Toxic Interactions of Divalent Metal Ions in Human Lung Cells. Available at SSRN 4824981.

Debad S, Allen D, Bandele O, Bishop C, Blaylock M, Brown P, Bunger MK, Crosby L, Daniel AB, Ferguson SS, Ford K. Trust your gut: Establishing confidence in gastrointestinal models-An overview of the state of the science and contexts of use. ALTEX-Alternatives to animal experimentation. 2024 May 15.

Obiako PC, Ayisire S, Sayes CM. Impact of Per-and Polyfluoroalkyl Substances on Oxidative Stress and Metabolic Biomarkers in Human Neuronal Cells. Available at SSRN 4760931.

2023

Pradhan SH, Liu JY, & Sayes CM*. (2023). Evaluating Manganese, Zinc, and Copper Metal Toxicity on SH-SY5Y Cells in Establishing an Idiopathic Parkinson’s Disease Model. International Journal of Molecular Sciences, 24(22), 16129. PMID: 38003318  PMCID: PMC10671677

Obiako P, Sevcik A, & Sayes CM*. (2023). Rapid enzymatic activity model (REAM) to decipher the toxic action of per- and polyfluoroalkyl substances. Food and Chemical Toxicology, 182, 114117. PMID: 37898236

Ayorinde T and Sayes CM*. (2023). An Updated Review of Industrially Relevant Titanium Dioxide and its Environmental Health Effects. Journal of Hazardous Materials Letters, 4:100085.

Solan ME, Schackmuth B, Bruce ED, Pradhan S, Sayes CM, and Lavado R. (2023). Effects of Short-Chain Per- and Polyfluoroalkyl Substances (PFAS) on Toxicologically Relevant Gene Expression Profiles in a Liver-on-a-Chip Model.  Environmental Pollution, 122610.  PMID: 37742859

Collom C, Pradhan SH, Liu JY, Liu J, Sharma V, Sayes CM*. (2023). Toxicity of binary mixtures of copper, lead, and glyphosate on neuronal cells. Journal of Hazardous Materials Advances, 11:100355.

Pradhan SH, Gibb M, Kramer AT, Sayes CM*. (2023). Peripheral (lung-to-brain) exposure to diesel particulate matter induces oxidative stress and increased markers for systemic inflammation. Environmental Research, 231(3):116267. PMID: 37257747

Gibb M and Sayes CM*. (2023). An In Vitro Alveolar Model Allows for the Rapid Assessment of Particles for Respiratory Sensitization Potential. International Journal of Molecular Sciences, 24(12):10104. PMID: 37373252; PMCID: PMC10298449

Sheikh A, Zechmann B, Sayes CM, Taube JH, & Greathouse KL (2023). A preparation of bacterial outer membrane with osmium tetroxide and uranyl acetate co-stain enables improved structural determination by transmission electron microscopy. Microscopy, dfad027. PMID: 37148329

Ameh T, Zarzosa K, Dickinson J, Braswell WE, & Sayes CM*. (2023). Nanoparticle surface stabilizing agents influence antibacterial action. Frontiers in Microbiology, 14:1119550. PMCID: PMC9947285. PMID: 36846763

Ameh T, Zarzosa K, Braswell WE, & Sayes CM*. (2023). Nanoparticle surface coatings produce distinct antibacterial effects that are consistent across diverse bacterial species. Frontiers in Toxicology, 5: 1119547. PMCID: PMC10022730. PMID: 36936540

Al Naggar Y*, Sayes CM, Collom C, Ayorinde T, Qi S, El-Seedi HR, Paxton RJ, Wang K. (2023). Chronic exposure to polystyrene microplastic fragments has no effect on honey bee survival but reduces feeding rate and body weight. Toxics 11:100.

2022

Liu JY and Sayes CM*. (2022). Lung surfactant as a biophysical assay for inhalation toxicology. Current Research in Toxicology, 4:100101. PMCID: PMC9849875. PMID: 36687216

Rothen-Rutishauser B, Gibb M, He R, Petri-Fink A, Sayes CM*. (2022). Human lung cell models to study aerosol delivery – Considerations for model design and development. European Journal of Pharmaceutical Sciences, 180:106337.  PMID: 36410570

Gibb M and Sayes CM*. (2022). An in vitro alveolar model allows for the rapid assessment of chemical respiratory sensitization with modifiable biomarker endpoints. Chemico-Biological Interactions 368:110232.  PMID: 36309140

Baldovinos Y, Archer A, Salamanca J, Strongin RM, Sayes CM*. (2022). Chemical Interactions and Cytotoxicity of Terpene and Diluent Vaping Ingredients. Chemical Research in Toxicology, 36(4):589-597.  PMID: 36279315. PMCID: PMC10114068.

Liu JY, Pradhan SH, Hussain S, Sayes CM*. (2022). Platform for Exposing Aerosolized Substances to Lung Surfactant and Alveolar Cells at the Air-Liquid Interface. ACS Chemical Health & Safety, 29(5):448-54.

Ameh T, Gibb M, Stevens MD, Pradhan SH, Braswell WE, and Sayes CM*. (2022). Silver and copper nanoparticles induce oxidative stress in bacteria and mammalian cells. Nanomaterials Jul 14;12(14):2402. PMID: 35889626

Liu JY and Sayes CM*. (2022). A Toxicological Profile of Silica Nanoparticles. Toxicology Research 11(4): 565–582. PMID: 36051665.  PMCID: PMC9424711

Lujan H, Mulenos MR, Carrasco D, Zechmann B, Sayes CM*. (2022) Engineered Aluminum Nanoparticle Induces Mitochondrial Deformation and is Predicated on Cell Phenotype. Nanotoxicology 24:1-8. PMID: 35077653

Liu J, Gibb M, Pradhan SH, Sayes CM*. (2022). Synergistic Cytotoxicity of Bromoacetic Acid and Three Emerging Bromophenolic Disinfection Byproducts against Human Intestinal and Neuronal Cells. Chemosphere 287(1):131794. PMID: 34438205

2021

Song S, Johnson KS, Lujan H, Pradhan SH, Sayes CM, Taube JH*. (2021). Nanoliposomal delivery of microRNA-203 suppresses migration of triple-negative breast cancer through distinct target suppression. Non-coding RNA 7(3):45. PMID: 34449670.  PMCID: PMC8395754

Al Naggar Y*, Brinkmann M, Sayes CM, Al-Kahtani SN, Dar S, El-Sedi HR, Giesy JP, Grünewald B. (2021). “Are Honey Bees at Risk from Microplastics?” Toxics 9:109. PMID: 34063384.  PMCID: PMC8156821

Patel I, Woodcock J, Beams R, Stranick SJ, Nieuwendaal R, Gilman JW, Mulenos MR, Sayes CM, Salari M, DeLoid G, Demokritou P, Harper B, Harper S, Ong KJ, Shatkin JA, Fox DM*. Fluorescently Labeled Cellulose Nanofibers for Environmental Health and Safety Studies. Nanomaterials. 2021 Apr 15;11(4):1015. 10.3390/nano11041015. PMID: 33921179; PMCID: PMC8071547.

Gibb M, Pradhan SH, Mulenos MR, Lujan H, Liu J, Ede JD, Shatkin JA, Sayes CM*. (2021). “Characterization of a Human In Vitro Intestinal Model for the Hazard Assessment of Nanomaterials Used in Cancer Immunotherapy”. Applied Sciences 11(5):2113.                                                                  

Sayes CM* and Singal M. (2021). “The link between delivered aerosol dose and inflammatory responses: Exposing a lung Cell Co-Culture system to selected allergens and irritants”. Journal of Aerosol Science 151:105677.

Liu J, Mulenos MR, Hockaday WC, Sayes CM, Sharma VK*. (2020). Ferrate(VI) pretreatment of water containing natural organic matter, bromide, and iodide: A potential strategy to control soluble lead release from PbO2(s). Chemosphere. 2021 Jan 263:128035. PMID: 33297053.

Liu J, Sayes CM, Sharma VK, Li Y, Zhang X*. (2021). Addition of lemon before boiling chlorinated tap water: A strategy to control halogenated disinfection byproducts. Chemosphere, 263:127954. PMID: 32854008; PMCID: PMC8134856.

2020

Ede JD, Ong KJ, Mulenos MR, Pradhan S, Gibb M, Sayes CM*, Shatkin JA. (2020). Physical, chemical, and toxicological characterization of sulfated cellulose nanocrystals for food-related applications using in vivo and in vitro strategies. Toxicology Research, 9(6):808-822. PMID: 33447365; PMCID: PMC7786165.

Mulenos MR, Lujan H, Pitts LR, Sayes CM*. (2020). Silver Nanoparticles Agglomerate Intracellularly Depending on the Stabilizing Agent: Implications for Nanomedicine Efficacy. Nanomaterials, 10(10):1953.  PMID: 33007984; PMCID: PMC7601179.

Liu J, Li Y, Jiang J, Zhang X, Sharma VK, Sayes CM*. (2020). Effects of ascorbate and carbonate on the conversion and developmental toxicity of halogenated disinfection byproducts during boiling of tap water. Chemosphere, 254:126890. PMID: 32957290; PMCID: PMC8056440.

Liu J, Olson C, Qiu N, Sayes CM*. (2020). Differential Cytotoxicity of Haloaromatic Disinfection Byproducts and Lead Co-exposures against Human Intestinal and Neuronal Cells. Chemical Research in Toxicology 2020 33(9):2401-2407. PMID: 32803957.

Pradhan SH, Mulenos MR, Steele LR, Gibb M, Ede JD, Ong KJ, Shatkin JA, Sayes CM*. (2020). Physical, chemical, and toxicological characterization of fibrillated forms of cellulose using an in vitro gastrointestinal digestion and co-culture model. Toxicology Research, 9(3):290-301. PMCID: PMC7329166.

Liu J, Lujan H, Dhungana B, Hockaday WC, Sayes CM, Cobb GP, and Sharma VK*. (2020). "Ferrate(VI) pretreatment before disinfection: An effective approach to controlling unsaturated and aromatic halo-disinfection byproducts in chlorinated and chloraminated drinking waters.” Environment International 1(138):105641. PMID: 32203804. PMCID: PMC7724572.

Lujan H, Romer E, Salisbury R, Hussain S, Sayes CM*. (2020 ). Determining the Biological Mechanisms of Action for Environmental Exposures: Applying CRISPR/Cas9 to Toxicological Assessments. Toxicological Sciences, 175(1):5-18. PMID: 32105327.

Salazar-Medina AJ, Velazquez-Contreras EF, Sugich-Miranda R, Santacruz H, Navarro RE, Rocha-Alonzo F, Islas-Osuna MA, Chen PL, Christian SGB, Romoser AA, Dindot SV, Sayes CM, Sotelo-Mundo RR*, Criscitiello MF. (2020). Immune response of human cultured cells towards macrocyclic Fe2PO and Fe2PC bioactive cyclophane complexes. PeerJ. 2020 8:e8956. PMID: 32341898; PMCID: PMC7179565.

Mulenos MR, Liu J, Lujan H, Guo B, Lichtfouse E, Sharma VK, Sayes CM*. (2020). “Copper, silver, and titania nanoparticles do not release ions under anoxic conditions”. Environmental Chemistry Letters 24:1-10.           

Ong KJ, Ede JD, Pomeroy-Carter CA, Sayes CM, Mulenos MR, Shatkin JA*. (2020). A 90-day dietary study with fibrillated cellulose in Sprague-Dawley rats. Toxicology Reports, 7:174-182. PMID: 32021807; PMCID: PMC6994281.

2019

Mulenos MR, Zechmann B, Sayes CM*. (2019). Sample preparation utilizing sputter coating increases contrast of cellulose nanocrystals in the transmission electron microscope. Microscopy. 68(6):471-474. PMID: 31696231.

Friedersdorf LE*, Bjorkland R, Klaper RD, Sayes CM, Wiesner MR. (2019). Fifteen years of nanoEHS research advances science and fosters a vibrant community. Nature Nanotechnology, 14(11):996-998.  PMID: 31695147.

Ameh T and Sayes CM*. (2019). The potential exposure and hazards of copper nanoparticles: A review. Environmental Toxicology and Pharmacology, 71:103220. PMID: 31306862.

McMinn B, Duval AL, Sayes CM*. (2019). An Adverse Outcome Pathway Linking Organohalogen Exposure to Mitochondrial Disease. Journal of Toxicology, 2019:9246495. PMID: 31057609; PMCID: PMC6463576.

Lujan H, Criscitiello MF, Hering AS, Sayes CM*. (2019). Refining In Vitro Toxicity Models: Comparing Baseline Characteristics of Lung Cell Types. Toxicological Sciences, 168(2):302-314.  PMID: 30657991.

Sharma VK*, Sayes CM, Guo B, Pillai S, Parsons JG, Wang C, Yan B, Ma X. (2019). Interactions between silver nanoparticles and other metal nanoparticles under environmentally relevant conditions: A review. Science of the Total Environment, 653:1042-1051.  PMID: 30759545.

Lujan H, Griffin WC, Taube JH, Sayes CM*. (2019). Synthesis and characterization of nanometer-sized liposomes for encapsulation and microRNA transfer to breast cancer cells. International Journal of Nanomedicine, 14:5159-5173. PMID: 31371954; PMCID: PMC6632672.

2018

Stewart M, Mulenos MR, Steele LR, Sayes CM*. (2018). “Differences Among Unique Nanoparticle Protein Corona Constructs:
A Case Study Using Data Analytics and Multi-Variant Visualization to Describe Physicochemical Characteristics”. Applied Sciences 8:2669-2684.

Sayes CM* and Singal M. (2018). “Optimizing a Test Bed System to Assess Human Respiratory Safety After Exposure to Chemical and Particle Aerosolization”. Applied In Vitro Toxicology 4(2): 193.

2017

Sayes CM* and Lujan H. (2017). Characterizing the Nano-Bio Interface Using Microscopic Techniques: Imaging the Cell System is Just as Important as Imaging the Nanoparticle System. Current Protocols in Chemical Biology, 9(3):213-231.PMID: 28910854.

Benton EN and Sayes CM*. (2017). “Environmental Factors Contribute to the Onset of Food Allergies”. Journal of Environmental Science and Public Health 1(1):27-43.        

Sayes CM*, Aquino GV, Hickey AJ. (2017). Nanomaterial Drug Products: Manufacturing and Analytical Perspectives. AAPS Journal, 19(1):18-25.                                                 PMID: 27822601.

2016

Adegboyega NF, Sharma VK*, Cizmas L, and Sayes CM. (2016). “UV light induces Ag nanoparticle formation: roles of natural organic matter, iron, and oxygen”. Environmental Chemistry Letters 14(3): 353-357.          

Clippinger AJ*, Ahluwalia A, Allen D, Bonner JC, Casey W, Castranova V, David RM, Halappanavar S, Hotchkiss JA, Jarabek AM, Maier M, Polk W, Rothen-Rutishauser B, Sayes CM, Sayre P, Sharma M, Stone V. (2016). Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials. Archives of Toxicology, 90(7):1769-83.  PMID: 27121469; PMCID: PMC4894935.

Song BK*, Nugent WH, Sayes CM, Bruce ED. (2016). Effects of Novel Oxygen Therapeutic on Systemic and Microcirculatory Variables in Sprague‐Dawley Rat Isovolemic Hemodilution Model. The FASEB Journal, 30:946-11.

Gueldner J, Sayes C, Abel E, and Bruce E. (2016). Emerging Associations of the ALDH2*2 Polymorphism with Disease Susceptibility. Journal of Drug Metabolism & Toxicology 7: 202.

Polk WW, Sharma M, Sayes CM, Hotchkiss JA, Clippinger AJ*. (2016). Aerosol generation and characterization of multi-walled carbon nanotubes exposed to cells cultured at the air-liquid interface. Particle and Fibre Toxicology, 13:20. PMID: 27108236; PMCID: PMC4842292.

For a complete list of publications, including those published before 2016, see Google Scholar.