Amanda Sevcik, Ph.D.

Biochemistry

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Bio:

Dr. Sevcik joined the post-doctoral program in the fall of 2021. She is a powerful addition to our lab because of her experience as a senior faculty lecturer and biochemistry lab coordinator for Baylor University.

Dr. Sevcik continues her work with nanotherapeutics, including nanoliposome synthesis loading and characterization. Her goal is to utilize the particles as drug delivery vehicles for both human and plant systems (USDA and NIH funded).

Amanda's passion for science, teaching, and learning shines through her work. We look forward to her future work and accomplishments as a member and Associate Research Scientist of the Sayes Group.

Education:

BS Biochemistry from Tarleton State University 2005

  • The research project involved the development of a purification scheme for the trypsin-like enzyme from the local Texas legume Sesbania vesicaria

PhD in Biochemistry from Baylor University, 2013

  • Biological evaluation of thiosemicarbazone moieties and their inhibitory effects against the enzyme cathepsin B in tumor cells

  • Evaluation of the mechanism of action of colchicine-like benzosuberene molecules targeting tubulin binding and inhibition of tubulin polymerization 

Career:

Senior Lecturer and Biochemistry Lab Coordinator, Dept of Chemistry and Biochemistry, Baylor University 2013-2021

Associate Research Scientist – The Sayes Group, Dept of Environmental Sciences, Baylor University 2021-

Memberships:

American Chemical Society (ACS)

American Society for Biochemistry and Molecular Biology (ASBMB)

Texas Society for Microscopy (TSM)

Publications:

  1. Charlton-Sevcik AK, Collom C, Liu JY, Hsieh YL, Stark N, Ede JD, Shatkin JA, Sayes CM. The impact of surface functionalization of cellulose following simulated digestion and gastrointestinal cell-based model exposure. International Journal of Biological Macromolecules. 2024 Jun 1;271:132603.

  2. Guo Y, Wang H, Gerberich JL, Odutola SO, Charlton-Sevcik AK, Li M, Tanpure RP, Tidmore JK, Trawick ML, Pinney KG, Mason RP, Liu L. Cancers. 2021; 13(19):4769.

  3. Strecker, T. E., Odutola, S. O., Lopez, R., Cooper, M. S., Tidmore, J. K., Charlton-Sevcik, A. K., Liu, L. Cancer letters, 2015, 369 (1), 229-241.

  4. Odutola, S., Strecker, T., Cooper, M., Tidmore, J., Charlton-Sevcik, A., MacDonough, M., Liu, L. (2015). The FASEB Journal, 29(1 Supplement), 897-5.

  5. Parker, E. N., Song, J., Kumar, G. K., Odutola, S. O., Chavarria, G. E., Charlton-Sevcik, A. K., Siemann, D. W. (2015). Bioorganic & medicinal chemistry, 23(21), 6974-6992.

  6. Song, Jiangli; Jones, Lindsay; Chavarria, Gustavo; Charlton-Sevcik, Amanda, Jantz, Adam; Johansen, Audra; Bayeh, Liela; Soeung, Victoria; Snyder, Lindsey K.; Lade, Shawn D. Jr.; Chaplin, David; Trawick, Mary Lynn; Pinney, Kevin, Bioorganic and Medicinal Chemistry Letters 23 (9) , 2801-2807, 2013.

  7. Tanpure, Rajendra P., Clinton S. George, Madhavi Sriram, Tracy E. Strecker, Justin K. Tidmore, Ernest Hamel, Amanda K. Charlton-Sevcik, David J. Chaplin, Mary Lynn Trawick, and Kevin G. Pinney. MedChemComm (2012): 3, no. 6, 720-724.

  8. Song, Jiangli; Jones, Lindsay; Kumar, G.D.; Conner, Elizabeth; Bayeh, Liela; Chavarria, Gustavo; Charlton-Sevcik, Amanda, Chaplin, David; Trawick, Mary Lynn; Pinney, Kevin ACS Med Chem Letters, 2012, 3 (6), 450-453.

  9. Rajendra P. Tanpure, Clinton S. George, Madhavi Sriram, Tracy E. Strecker, Justin K. Tidmore, Ernest Hamel, Amanda K. Charlton-Sevcik, David J. Chaplin, Mary Lynn Trawick, and Kevin G. Pinney MedChemComm, 2011, 3, 720-724.

  10. G. D. Kishore Kumar, Gustavo E. Chavarria, Amanda K. Charlton-Sevcik, Grace Kim Yoo, Jiangli Song, Tracy E. Strecker, Bronwyn G. Sim, David J. Chaplin, Mary Lynn Trawick, Kevin G. Pinney Bioorganic and Medicinal Chemistry Letters, 2010, 20, 6610.

  11. G. D. Kishore Kumar, Gustavo E. Chavarria, Amanda K. Charlton-Sevcik, Wara M. Arispe, Matthew T. MacDonough, Tracy E. Strecker, Shen-En Chen, Bronwyn G. Siim, David J. Chaplin, Mary Lynn Trawick, and Kevin G. Pinney, Bioorg. Med. Chem. Lett., 2010, 20, 1415-1419.

  12. Charlton, Amanda K.; Sevcik, Richard S.; Tucker, Dorie A.; Schultz, Linda D Journal of Chemical Education, 2007, 84 (5), 826-828.

  13. Charlton, Amanda K.; Daniels, Charlisa R.; Wold, Rhiannon M.; Pustejovsky, Eric; Acree, William E.; Abraham, Michael H. Journal of Molecular Liquids, 2005, 116(1), 19-28.

  14. Daniels, Charlisa R.; Charlton, Amanda K.; Wold, Rhiannon M.; Pustejovsky, Eric; Furman, Ashley N.; Bilbrey, Adam C.; Love, Jermica N.; Garza, Jacob A.; Acree, William E.; Abraham, Michael H. Physics and Chemistry of Liquids, 2004, 42(5), 481-491.

  15. Daniels, Charlisa R.; Charlton, Amanda K.; Acree, William E.; Abraham, Michael H. Physics and Chemistry of Liquids, 2004, 42(3), 305-312.

  16. Daniels, Charlisa R.; Charlton, Amanda K.; Wold, Rhiannon M.; Moreno, Rebekah J.; Acree, William E.; Abraham, Michael H Physics and Chemistry of Liquids, 2004, 42(6), 633-641.

  17. Daniels, Charlisa R.; Charlton, Amanda K.; Wold, Rhiannon M.; Acree, William E., Jr.; Abraham, Michael H. Canadian Journal of Chemistry, 2003, 81(12), 1492-1501.

  18. Daniels, Charlisa R.; Charlton, Amanda K.; Wold, Rhiannon M.; Pustejovsky, Eric; Furman, Ashley N.; Bilbrey, Adam C.; Love, Jermica N.; Garza, Jacob A.; Acree, William E. Physics and Chemistry of Liquids, 2003, 41(6), 599-603.

  19. Taylor, Priscilla G.; Tran, Anh M.; Charlton, Amanda K.; Daniels, Charlisa R.; Acree, William E., Jr. Journal of Chemical and Engineering Data, 2003, 48(6), 1603-1605.

  20. Charlton, Amanda K.; Daniels, Charlisa R.; Acree, William E., Jr.; Abraham, Michael H. Journal of Solution Chemistry, 2003, 32(12), 1087-1102.